Amniocentesis Research Today is a free monthly online journal that collates and summarizes the latest research about Amniocentesis, including details on pregnancy, prenatal screening, diagnosis, risks, down syndrome.

Triploidy in a growth discordant twin pregnancy after intracytoplasmic sperm injection treatment. Case report.

Mendilcioglu I, Ozcan M, Bagci G, Simsek M, Kursun S, Luleci G, Taskin O

Department of Obstetrics and Gynaecology, Akdeniz University, School of Medicine, Antalya, Turkey. imendilcioglu@yahoo.com

OBJECTIVE: We report on a case of a triploidy in one fetus of a twin pregnancy who presented with the findings of growth discordance. METHODS: Three weeks' difference between fetuses in ultrasonographic measurements in the first trimester was observed in a twin pregnancy following intracytoplasmic sperm injection (ICSI) treatment for male infertility. Hydrocephaly developed in the growth-discordant fetus subsequently. Amniocentesis for both fetuses and selective feticide for the abnormal one was performed at 19 weeks' gestation through a single insertion. Fetal karyotype of the abnormal one was 69,XXX and the healthy one was 46,XX. CONCLUSION: Early developed growth discordance in a twin pregnancy may be a sign of chromosomal abnormality such as triploidy. Those cases should be karyotyped without delay to decrease preterm delivery risk of possible selective feticide.

Published 15 December 2005 in Fetal Diagn Ther, 21(1): 65-7.
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